Why Your Lab Rat Might Feel "Off" After Starting Glutathione (And What To Do About It)

Derek Pruski

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4h (edited) • Peptide Tips

Why Your Lab Rat Might Feel "Off" After Starting Glutathione (And What To Do About It)

If your lab rat has started glutathione and felt surprisingly worse before feeling better, this is common.

Here's what's actually happening:

Why Some Lab Rats Experience Initial Side Effects:

Detox Overload – Glutathione is the body's master detoxifier. When levels spike suddenly, it can mobilize stored toxins faster than elimination pathways can handle them. This can trigger headaches, fatigue, or mild nausea in the lab rat.

Herxheimer Reaction – As toxins get released into the system, the lab rat might experience temporary flu-like symptoms. This "die-off" response usually means the glutathione is working, but the body needs time to clear what's being released.

Baseline Depletion – If the lab rat was already severely depleted, the sudden increase can create an imbalance as the body scrambles to adjust and redistribute resources.

How To Make The Transition Smoother:

✅ Start low and go slow: Begin with 50mg 1-3x per week, then gradually work up to 200mg 1-3x per week over several weeks

✅ Keep the lab rat well-hydrated to support detox pathways

✅ Support liver function with NAC, milk thistle, or a clean, whole-foods diet

✅ Be patient – these effects typically resolve within days to a couple weeks

Bottom line: The lab rat feeling temporarily worse doesn't mean glutathione isn't right for them. It often means the body is adapting to powerful cellular support. Give it time, adjust dosing if needed, and most lab rats find these initial effects fade as their system recalibrates.

PS: I think 100mg was a bit much for my lab rat, who is currently sick.

Has your lab rat experienced this? Drop your experience below 👇

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