There is chatter online about ghk-cu not working as well with bac water and instead to use a different solution such as PBS. I have been running ghk going on 5-6 weeks now m-f doing roughly 1.5-2mg per day on average during that time. I have maybe noticed some mild effects on my face but nothing remarkable and I’m sure others are also experiencing some disappointment with the results. I found a thread talking about how it can be more effective at actually replacing skin tissue with healthier new tissue if you reconstitute it with a different solution than BAC and want everybody’s take on this.