A lot of people hear the word detox and immediately picture a 3-day juice cleanse.
That’s not what I’m talking about.
When I talk about detox, I’m talking about biotransformation—your body’s built-in system for processing and eliminating the chemical load we’re all exposed to. And that load is… not small.
Pesticides, plastics, exhaust, fragrances, flame retardants, forever chemicals, mold toxins—you name it, it’s in the mix.
Your liver wasn’t designed for modern chemistry. None of ours were.
Here’s the part that matters:
Your detox system runs in three real biochemical phases:
Phase 1 — Activation
Your liver transforms toxins into intermediate forms. Some become more reactive here. Totally normal.
Phase 2 — Conjugation
You attach chemical groups (methylation, glutathione, amino acids, etc.) to neutralize them.
Phase 3 — Elimination
You move them out through the gut, kidneys, skin, lymph.
This phase is where things often fall apart—especially with estrogen clearance.
Sluggish Phase 3 = classic estrogen dominance symptoms.
Your microbiome is a major player in all of this. Gut bacteria produce enzymes that help Phase 2 and Phase 3 actually function. When the gut is irritated or imbalanced, detox slows down even if your diet is “perfect.”
And when your detox capacity gets overwhelmed, you hit TILT—Toxicant-Induced Loss of Tolerance.
That’s when you start reacting to things you used to handle easily: foods, fragrances, alcohol, stress. It’s not random—your tolerance literally drops.
This isn’t fringe.
This isn’t optional.
This is basic human physiology that a lot of people never get taught.
What’s been your experience with detox?
Or if you’ve never done anything structured,
what questions do you still have about how detox actually works?
Jump into the comments—curious to hear where everyone’s at.
Dr G