“A new paper in the journal Psychedelics takes apart one of the psychedelic renaissance's most repeated stories: that toad-derived 5-MeO-DMT is ancient Comcáac (Seri) medicine.
Researchers Ortiz Bernal, Raison, Vargas Prieto, and Davis confirm genuine, centuries-old plant-based 5-MeO-DMT use in Caribbean and South American snuffs.
The toad version has no such record. The Comcáac narrative traces to 2011, introduced by a Sonora nonprofit and popularized by Octavio Rettig Hinojosa's book, then spread through documentaries and retreat circuits, now reaching Tohono O'odham and Yoreme communities too.
The authors call this pattern fabricated ancestrality, recent invention dressed as deep tradition to gain legitimacy in global psychedelic networks.
The ecological cost is real: demand has pushed prices to $50,000 per kilogram, and Incilius alvarius, the only toad that makes the compound, is already gone from California and threatened in New
Their ask is simple, historical honesty, synthetic 5-MeO-DMT over wild extraction, and conservation built in, not added after the damage.
Source: Fabricated ancestrality: The Sonoran Desert toad, psychedelic globalization, and the ecological politics of 5-MeO-DMT A.M. Ortiz Bernal et.al. doi:0.1016/j.psyche.2026.100012”