Oct '25 • General discussion
Lesson 1 – The HPT Axis: How Your Brain Controls Testosterone
In this lesson, I break down the HPT Axis: the communication loop between your brain, pituitary, and testes that controls your testosterone and fertility.
You’ll learn:
• How the hypothalamus releases GnRH to trigger your pituitary
• How LH activates Leydig cells to produce testosterone
• How FSH stimulates Sertoli cells for sperm production
• Why rising estrogen feeds back through Kisspeptin neurons to shut down GnRH
• And how therapies like enclomiphene, hCG, and testosterone affect this system
Understanding this axis is the foundation of performance medicine.
👉 Comment below what you found most interesting — and what part of this axis you want me to teach next.
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Lesson 1 – The HPT Axis: How Your Brain Controls Testosterone
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