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What it is VIP is a naturally occurring neuropeptide involved in communication between the nervous system, immune system, and gut. What it’s known for Supports neuro-immune balance Plays a role in gut motility and absorption Influences vasodilation (blood flow signaling) Involved in circadian rhythm and stress signaling Why people talk about it VIP sits at the intersection of brain ↔ gut ↔ immune signaling, which is why it shows up in discussions around bio-optimization and recovery-focused research. Quick notes Short half-life Very signaling-specific Typically discussed in advanced protocols

CATEGORY Cognitive / Neuroprotective WHAT IT IS Semax is a synthetic peptide derived from ACTH (4–10). It was developed for cognitive enhancement and neurological protection and has been used clinically in parts of Eastern Europe. WHAT IT DOES • Enhances focus and mental clarity • Improves learning and memory • Supports mood and motivation • Promotes neuroplasticity via BDNF signaling • Helps protect brain tissue under stress HOW IT WORKS • Modulates melanocortin receptors • Increases BDNF and TrkB activity • Influences dopamine and serotonin pathways • Reduces neuroinflammation and oxidative stress COMMON USE CASES • Brain fog • Focus and productivity • Learning and retention • Neurological recovery • Mental fatigue and burnout ADMINISTRATION Intranasal delivery is most common due to direct CNS access and rapid onset. TYPICAL RESEARCH DOSING 300–600 mcg per day Often split into 2–3 doses HOW IT FEELS (USER-REPORTED) • Clearer thinking • Faster recall • Increased motivation • Calm but focused mental state COMPARE Semax → focus-forward and stimulating Selank → calming and anxiolytic NOTES Semax does not act like a stimulant. Effects are often described as clean mental clarity rather than jittery energy.